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The patients had a history of at least 4 partial-onset seizures per month in spite of receiving 1 or more AEDs at therapeutic concentrations and in 2 of the trials were observed on their established AED regimen during baselines that varied between 8 to 12 weeks. This evidence suggests, although it certainly does not prove, that the high SUDEP rates reflect population rates, not a drug effect.
Respiratory adverse reactions included nasal congestion, cough, and apnea. In animal models designed to detect anticonvulsant activity, lamotrigine was effective in preventing seizure spread in the maximum electroshock MES and pentylenetetrazol scMet tests, and prevented seizures in the visually and electrically evoked after-discharge EEAD tests for antiepileptic activity.